在韩国,基因决定的酒精消费和癌症风险
Keum Ji Jung1, Ji Woo Baek1, Sang Yop Shin2
1Institute for Health Promotion, Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
这项研究发现,基因决定的酒精消费与直肠癌和肝癌有因果关系. 这种联系对于60岁以上的乙型肝炎表面抗原阴性患者的肝癌尤为强烈.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 酒精消费是众所周知的各种癌症的风险因素.
- 了解酒精摄入量与癌症之间的因果关系对于公共卫生至关重要.
- 遗传倾向可能会影响酒精消费水平和随后的癌症风险.
研究的目的:
- 调查遗传决定的酒精消费与主要癌症类型之间的因果关系.
- 为了识别受影响于影响酒精摄入量的遗传因素影响的特定癌症.
主要方法:
- 利用了129,324名韩国癌症预防研究II (2004-2013) 参与者的数据.
- 进行了全基因组关联研究 (GWAS),以计算饮酒的遗传风险得分.
- 估计了基因确定的酒精消耗 (GDAC) 并分析了与癌症发病率的关联,证实到2020年.
主要成果:
- 基因决定的酒精消耗 (GDAC) 显示与直肠和肝癌有显著的因果关系.
- 与其他癌症类型没有发现因果关系.
- 对于肝癌,在60岁以上的乙型肝炎表面抗原 (HBsAg) 阴性个体中观察到强烈的关联,高GDAC组显示风险增加.
结论:
- 基因决定的酒精消费因果关系与直肠和肝癌有关,特别是在HBsAg阴性个体中.
- 建议进行进一步的长期研究,以探索与其他癌症类型的潜在联系.
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