心神经活动在运动期间增加,以增强冠状动脉血流
Julia Shanks1, Mridula Pachen1, Joshua W-H Chang1
1Manaaki Manawa - The Centre for Heart Research, Department of Physiology, University of Auckland, Grafton, New Zealand.
与以前的看法相反,心神经活动在运动期间增加. 血管活性肠 (VIP) 在运动期间调节冠状动脉血流方面发挥着关键作用.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的调节规则
- 运动生理学 运动生理学
背景情况:
- 运动期间阴道神经活动的作用一直在争论中",完全的阴道退出"是一个常见的假设.
- 最近的研究挑战了这一观念,表明在体育活动期间阴道系统和心脏功能之间存在更复杂的相互作用.
研究的目的:
- 为了研究心脏管活动在运动期间增加的假设.
- 为了确定参与维持心脏功能和运动期间冠状动脉血流的神经递质,除了乙胆.
主要方法:
- 在跑步机运动期间,在有意识的绵羊中,慢性地直接记录心脏神经活动,心脏输出,冠状动脉血流和心率.
- 药理上对乙胆和血管活性肠 (VIP) 的阻断,以及阴道分支的化,以评估它们的作用.
主要成果:
- 直接记录的心神经活动在运动期间显著增加.
- 左心虚支部缩减弱的运动诱导的冠状动脉血流量,心脏输出和心率的增加.
- VIP对抗性,但不是乙胆阻塞,在运动期间显著降低冠状动脉血流,类似于阴道缩.
结论:
- 心脏神经活动在运动期间增加,对于维持心脏功能至关重要.
- 血管活性肠 (VIP) 被确定为运动期间冠状动脉血流的动态调节的主要调解剂.
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