糖尿病伤口愈合治疗的现状和未来前景:临床试验的现有证据
Jyotsana Dwivedi1, Pranjal Sachan1, Pranay Wal1
1Department of Pharmacy, PSIT-Pranveer Singh Institute of Technology, Kanpur, India.
Current diabetes reviews
|August 29, 2023
概括
本综述探讨了用于治疗慢性糖尿病伤口的先进抗菌水凝. 这些创新材料旨在通过对抗感染和促进糖尿病患者的组织修复来加速愈合.
科学领域:
- 生物材料科学 生物材料科学
- 伤口治愈研究研究 伤口治愈研究
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病是一种日益严重的全球健康问题,其特点是高血糖,导致愈合缓慢,易受感染的伤口.
- 糖尿病伤口,特别是足部,由于生物膜,缺氧,氧化应激和血管功能受损等因素而复杂化.
- 有效的糖尿病伤口管理对于预防截肢等严重并发症至关重要.
研究的目的:
- 审查抗菌水凝对慢性糖尿病伤口管理的最新进展.
- 突出水凝在促进伤口愈合方面的多方面的作用,包括抗菌作用,抗炎作用和增强血管化的作用.
- 讨论功能性水凝作为改善糖尿病伤口护理结果的治疗策略的潜力.
主要方法:
- 文献综述,重点关注最近的研究和抗菌水凝开发的突破,用于糖尿病伤口治疗.
- 分析与慢性伤口愈合相关的水凝性质,例如抗微生物疗效,生物相容性和治疗特征.
- 综合关于利用水凝用于复杂的糖尿病伤口病理的挑战和机会的信息.
主要成果:
- 抗菌水凝在抗击细菌感染和糖尿病伤口中的生物膜形成方面表现出显著的潜力.
- 功能性水凝可以提供多种治疗益处,包括持续的药物释放,伤口环境的调节和血管生成的促进.
- 最近的创新在开发响应伤口微环境的智能水凝方面表现有前途,以提供有针对性的治疗.
结论:
- 抗菌水凝是一种有希望的治疗途径,可以加速慢性糖尿病伤口的愈合.
- 需要进一步的研究和开发来优化水凝配方,以提高疗效和临床转化.
- 多功能水凝提供了一种可行的策略,以解决与糖尿病伤口管理相关的复杂挑战,并减少相关的发病率.
相关概念视频
Phases of Wound Repair
6.1K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.1K
Diabetes: Management and Pharmacotherapy
310
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
310
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Peripheral Artery Disease IV: Nursing Management
12
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
12
Current Trends in Nursing II
1.2K
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
1.2K
Pathophysiology of Diabetes
986
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
986


