在结肠直肠癌查中使用多级负二项模型检测活体吸烟
Nittaya Phuangrach1, Pongdech Sarakarn2,3
1Ph.D. candidate in Epidemiology and Biostatistics, Faculty of Public Health, Khon Kean University, Khon Kaen, Thailand.
Asian Pacific journal of cancer prevention : APJCP
|August 29, 2023
概括
多级负双项分析对于结直肠癌查数据至关重要,特别是过度分散的数据. 标准方法可能会误解活跃吸烟.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
- 公共卫生 公共卫生
背景情况:
- 多层次分析被广泛使用,但其在结直肠癌 (CRC) 查中的应用,特别是在社区层面,需要澄清.
- 本研究解决了对使用多级负二项式分析用于CRC查数据的实际指南的需求.
研究的目的:
- 在CRC查中解释多层负二项式分析的应用.
- 使用现实世界的数据,将多层负二项式分析与标准负二项式方法进行比较.
主要方法:
- 分析了泰国CRC查随机对照试验中的2,475例便免疫化学测试 (FIT) 病例.
- 标准负二项式和多级负二项式方法的比较,考虑活跃吸烟和便中的血红蛋白 (f-Hb) 度.
主要成果:
- 标准负二项法显示,活跃吸烟与f-Hb度有显著的相关性 (IRRadj = 1.47).
- 多级负二项式方法对活跃吸烟和f-Hb度 (IRRadj = 1.30) 产生了无意义的结果.
- 在两种统计方法之间观察到效果大小和值的显著差异.
结论:
- 对于零膨胀或过度分散的结果的CRC查数据,标准统计方法可能不足.
- 层次数据结构和上下文因素需要使用多层次建模.
- 在f-Hb度的过度分散表明多层次建模的实用性,以改善未来研究中的统计分析.
更多相关视频
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
300
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
14.5K
相关概念视频
Statistical Methods for Analyzing Epidemiological Data
408
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
408
Cancer Survival Analysis
381
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
381
Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
Comparing the Survival Analysis of Two or More Groups
222
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
222
