过去或现在;哪些暴露更好地预测代谢衰老? 在Doetinchem队列研究
Annelot P Smit1,2, Gerrie-Cor M Herber1, Lieke M Kuiper1,3
1Center for Prevention, Lifestyle and Health, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
概括
使用暴露相关暴露预测代谢衰老的纵向和横截面数据显示了类似的性能. 生物和生活方式因素,包括饮食,是男性和女性的关键预测因素.
科学领域:
- 老年学与公共卫生
- 代谢学和暴露学.
- 流行病学研究 流行病学研究
背景情况:
- 个体的衰老速度各不相同,这可能反映在代谢特征 (代谢体衰老) 中.
- 预测代谢衰老对公共健康至关重要,但纵向与横截面暴露数据的价值仍然不清楚.
- 暴露组包括环境,生活方式和生物因素,为衰老过程提供了潜在的预测因素.
研究的目的:
- 调查暴露与暴露相关的暴露作为代谢衰老的预测因素.
- 为了比较横截面与纵向暴露数据的预测值.
- 确定男性和女性代谢衰老的关键预测因素.
主要方法:
- 利用了来自杜廷克姆队列研究 (DCS) 的4459名参与者 (年龄在36-75岁) 的数据.
- 使用MetaboHealth算法计算代谢年龄.
- 采用随机森林建模来评估预测性能,并根据15年的横截面和纵向暴露确定重要的预测因素.
主要成果:
- 在男性 (R2 6.8 与 5.8) 和女性 (R2 14.8 与 14.4) 的横截面和纵向暴露中,预测性能相似.
- 生物和饮食暴露是两性代谢衰老最重要的预测因素.
- 吸烟行为 (男性) 和避孕药使用/绝经状态 (女性) 也是重要的预测因素.
结论:
- 对暴露史的纵向评估没有提供与横截面测量相比的附加值,用于预测该队列中的代谢衰老.
- 虽然确定了预测因素,但对代谢衰老的整体预测性能是适度的.
- 代谢衰老的关键预测因素主要是生物和生活方式相关的,有一些性别特异性差异.
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