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关于当前治疗方法和卵巢癌治疗所涉及的挑战的全面审查
Saika Saman1, Nimisha Srivastava1, Mohd Yasir2
1Department of Pharmaceutics, Faculty of Pharmacy, Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh, Sector 125, Noida, 201313, India.
Current cancer drug targets
|August 29, 2023
概括
卵巢癌的治疗面临着由于晚期诊断和多药耐药性 (MDR) 的挑战. 纳米载体药物输送系统通过增强向化疗输送和减少副作用,为克服MDR提供了一个有希望的策略.
科学领域:
- 在瘤学瘤学.
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 卵巢癌 (OC) 是一种主要的妇科恶性瘤,通常在晚期 (III/IV) 诊断,导致预后不佳.
- 腹腔内化学疗法由于多药性耐药性 (MDR),复发和精确向癌症的挑战而显示出有限的疗效.
- 传统的治疗方法与耐药性,施用途径和显著的细胞毒性副作用作斗争.
研究的目的:
- 审查传统的卵巢癌治疗方法,重点关注基于纳米载体的联合交付系统.
- 探索纳米载体如何通过各种机制克服多药性耐药性 (MDR).
- 突出被动和主动向策略在改善卵巢癌药物输送和疗效方面的作用.
主要方法:
- 关于卵巢癌治疗方法的当前文献的综述.
- 对用于卵巢癌的基于纳米载体的药物递送系统 (DDS) 的分析.
- 讨论被动向 (例如,增强透性和保留 - EPR效应) 和主动向 (受体特异性) 策略.
- 检查纳米载体机制克服多药性耐药性 (MDR),包括绕过药物排泄.
主要成果:
- 纳米载体通过被动和主动向增强化疗药物向瘤部位的输送,减少全身毒性.
- 增强的透性和保留 (EPR) 效应改善了瘤部位的药物生物可用性.
- 纳米载体可以绕过药物排泄,这是多药耐药性 (MDR) 的关键机制.
结论:
- 定制的纳米载体对于优化卵巢癌中细胞内药物输送和内分布至关重要.
- 纳米载体联合递送系统显示出克服多药性耐药性 (MDR) 和提高治疗疗效的潜力.
- 未来的卵巢癌治疗可能涉及纳米载体与瘤疫苗和基因疗法等新方法相结合.
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