全球肺功能倡议预测方程在香港的适用性 中国儿童儿童
Kate C Chan1,2,3, Huichen Zhu4, Michelle Yu1
1Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Pediatric pulmonology
|August 29, 2023
概括
这项研究评估了全球肺功能倡议 (GLI) 对香港儿童的螺旋计方程,并发现它们适用. 开发了使用通用附加模型的位置,规模和形状 (GAMLSS) 的新预测方程,包括年龄,身高和体重.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统生理学 呼吸系统生理学
- 生物统计学 生物统计学
背景情况:
- 螺旋计对于诊断儿科肺部疾病至关重要.
- 全球肺功能倡议 (GLI) 的方程被广泛使用,但需要进行本地验证.
- 香港中华儿童的肺功能数据是需要改进这些预测的.
研究的目的:
- 评估现有的GLI螺旋计预测方程在香港儿童中的适用性.
- 使用GAMLSS建模,为香港儿童开发新的螺旋测量预测方程.
- 在这个人群中确定肺功能的关键预测因素.
主要方法:
- 从随机选择的学校招募886名健康的中国儿童和青少年 (6-17岁).
- 螺旋测量测量用GLI-2012 (亚洲东部) 和GLI-2022 (全球种族中立) 方程转换为z分数.
- 使用位置,尺度和形状 (GAMLSS) 建模的通用添加模型开发新的预测方程.
主要成果:
- GLI-2012方程显示FEV1和FVC的z-score平均值为正值,FEV1/FVC比率为负值.
- 根据GLI-2022方程,FEV1和FVC的z-score平均值为负值,FEV1/FVC比率为正值.
- 年龄和身高是所有螺旋指数的重要预测因素;体重在GAMLSS模型中额外预测了FVC和FEV1.
结论:
- GLI预测方程在香港的中国儿童中显示出适用性,在生理界限内的微小偏差.
- GLI-2012方程可能略低估计FEV1和FVC,而GLI-2022可能会高估它们.
- 在GAMLSS模型中,年龄,身高和体重被确定为重要的预测因素,从而为这一群体提供了精细的螺旋测量预测.
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