在过敏性鼻炎下降低轮和免疫治疗的成本效益分析
Michael Yong1, Kaishan Aravinthan2, Keshinisuthan Kirubalingam3
1Department of Otolaryngology - Head & Neck Surgery, Stanford University School of Medicine, Stanford, California, U.S.A.
The Laryngoscope
|August 29, 2023
概括
对于带有鼻阻塞的过敏性鼻炎,在皮下过敏原免疫疗法 (SCIT) 之前的下轮缩 (ITR) 是最具成本效益的策略. 这种方法比其他治疗持续症状的方法提供了更好的价值.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏和免疫学 过敏和免疫学
- 卫生经济学 卫生经济学
背景情况:
- 过敏性鼻炎 (AR) 经常导致鼻腔阻塞,原因是亚托皮下层轮缩 (ITH).
- 目前的指导方针建议在药物治疗失败时进行皮下过敏原免疫疗法 (SCIT).
- 与其他治疗方法相比,劣势轮减速 (ITR) 的成本效益仍然不清楚.
研究的目的:
- 为了比较不同治疗策略的成本效益对AR与鼻腔阻塞.
- 评估涉及药物治疗,过敏测试,SCIT和ITR的治疗序列.
主要方法:
- 进行了为期5年的成本效益分析.
- 他们比较了四种治疗组合:单药疗法,SCIT,SCIT然后ITR对不响应者,ITR然后SCIT对不响应者.
- 我们计算了增量成本效益比率 (ICER).
主要成果:
- 在SCIT之前优先考虑ITR,成为最初药物治疗失败的患者最具成本效益的策略.
- 在95.4%的情景中,概率学敏感性分析证实了这一发现.
- ITR证明了成本效益,即使与排卵管结合.
结论:
- 低轮缩减 (ITR) 是一种成本效益高的治疗方法,用于因ITH导致鼻腔阻塞的AR患者.
- 在针对持续症状进行免疫治疗之前,应考虑ITR.
- 这种策略为当前的治疗模式提供了有价值的替代方案.
相关概念视频
Drugs Used in Lower Respiratory Disorders: Overview
487
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
487
Drugs Used in Upper Respiratory Disorders: Overview
290
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
290
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
342
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
342
Chronic Pharyngitis
2.7K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
2.7K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
298
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
298


