语下布普伦诺芬对ICU疼痛控制的有效性
Asad E Patanwala1,2, Benjamin Moran3, Charlotte Johnstone4
1Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
Critical care medicine
|August 29, 2023
概括
在重症患者中,布普伦诺芬下舌和氧化可提供类似的疼痛控制和阿片类药物消耗. 在ICU患者无法服用口服药物的情况下,布普伦诺芬潜舌是一种可行的替代方案.
科学领域:
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 有效的疼痛管理对于重症病患在重症监护室 (ICU) 中至关重要.
- 通常使用阿片类止痛药,但正在为具有特定给药途径限制的患者探索替代策略.
研究的目的:
- 为了比较布普伦诺芬下舌治疗与口服/肠道氧化在ICU患者疼痛控制方面的疗效.
- 评估和比较两个治疗组之间的阿片类药物消费在ICU入院期间.
主要方法:
- 追溯,并行队列研究,包括1070名入院于一般医疗或外科ICU的患者.
- 倾向性得分匹配用于创建可比较的组,接受口服/肠道布普伦诺芬或氧化.
- 主要结局:显著疼痛的概率,由数值评分表 (NRS) 或行为疼痛表 (BPS) 定义.
主要成果:
- 显著疼痛的中位数概率在两组之间是相似的 (0.16对于布普伦诺芬而不是0.17对于氧化;p=0.50).
- 中位数阿片类药物消费 (MME) 是可比的 (65 对于布普伦诺芬,而70 对于氧化;p=0.73).
- 每个ICU日的MME中位数也相似 (22为两组;p=0.38).
结论:
- 在ICU的疼痛管理和阿片类药物消耗方面,口服布普伦诺芬表现出与口服/肠道氧化相似的有效性.
- 布普伦诺芬下舌是一种适合于不能接受口服或肠道药物治疗的ICU患者的替代品.
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