含有化物的阿洛马尔托尔在1.1'-碳化胺醇中介转化为替代的3 - 乙四酸
Andrey N Komogortsev1, Boris V Lichitskii1, Valeriya G Melekhina1
1N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Leninsky Pr., 47, Moscow 119991, Russian Federation. dna5@mail.ru.
这项研究探讨了allomaltol化物与1.1'-carbonyldiimidazole (CDI) 的反应,产生新的四酸衍生物. 研究还揭示了特定基质的反应途径的变化,形成了pyrano[3,2-b]pyrans.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 药用化学 医学化学
背景情况:
- 阿洛马尔托尔衍生物是有机合成中的多功能构建块.
- 化物和1,1'-碳乙烯胺醇 (CDI) 是异环化学中常见的试剂.
- 了解新的反应途径对于开发新的合成方法至关重要.
研究的目的:
- 为了研究含有allomaltol的化物和1.1'-carbonyldiimidazole (CDI) 之间的反应.
- 阐明产品的结构,并确定关键的中间产品.
- 探索这种新合成转换的范围和局限性.
主要方法:
- 在各种条件下,阿洛马尔托尔化物与CDI反应.
- 用于结构阐明的光谱分析 (NMR,MS).
- 用X射线结晶学确定关键化合物的结构确认.
- 使用多种类型的替代性阿洛马尔托和碳胺单元进行测试.
主要成果:
- 反应成功地将3 - 基-4 - 皮拉衍生物转化为3 - 乙四酸与pyrrolidin-2-one部分.
- 关键中间体被确定为替代的6-oxa-1-azaspiro[4.5]dec-7-ene-2,9-diones. 的关键中间体.
- 射线分析证实了最终产品和中间产品的结构.
- 含甲基的化物和胺酸导致了不同的反应路径,形成了替代的pyrano[3,2-b]pyrans.
结论:
- 已经建立了一种新的合成途径,以获得含有pyrrolidin-2-one部分的酸衍生物.
- 反应机制涉及螺旋环中间体,提供了对异环合成的见解.
- 反应的结果对化替代物的性质敏感,允许复杂的异环系统的分离合成.
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