抗生素耐药性,包括COVID-19后的数据
Lyudmila Boyanova1, Georgi Dimitrov1, Raina Gergova1
1Department of Medical Microbiology, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria.
Expert review of clinical pharmacology
|August 29, 2023
概括
在Clostridioides difficile感染 (CDI) 中抗生素耐药性在全球范围内有所不同. 监测耐药性对于有效治疗至关重要,在CDI治疗中建议使用菲达克索米辛和万科米辛.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 困难菌感染 (CDI) 构成了重大的公共卫生挑战.
- 了解当前抗生素耐药性模式对于优化治疗策略至关重要.
研究的目的:
- 更新有关各个国家的Clostridioides difficile抗生素耐药性的数据.
- 为改善C. difficile感染的治疗方法提供信息.
主要方法:
- 来自20个国家的C. difficile抗生素敏感性数据的系统审查和元分析.
- 对万科米辛,美特罗尼达,莫西弗洛克萨辛,克林达米辛,红色胺素,利法,伊米佩内姆,提格环素和菲达克索米辛的耐药性率的分析.
主要成果:
- 在不同国家,研究期间和循环中的核型中观察到C. difficile抗菌敏感性的显著变化.
- 对于莫西弗洛克萨辛 (34.9%) 和克林达米辛 (61.0%),观察到高耐药率,具有显著的变异性.
- 菲达克索米辛的抗药性较低 (0-2%),而万科米辛 (4.7%) 和美特罗尼达 (2.6%) 的抗药性平均值较低,尽管在一些研究中范围很广.
结论:
- 由于观察到的抗药性变异,定期监测C. difficile对抗生素敏感性至关重要.
- 建议在CDI治疗中使用菲达克索米辛和万科米辛,而适合轻度病例的甲尼达.
- 新兴的疗法和持续的监测是必要的,以对抗不断变化的耐药性模式.
关键词:
抗生素 抗生素是一种抗生素.克洛斯特里迪奥伊德斯困难菌克洛斯特里迪亚姆困难菌 (Clostridium difficile) 是一种难以灭绝的菌种.过度病毒性 过度病毒性多种药物耐药性多种药物耐药性电阻的阻力可以树脂类型 树脂类型 树脂类型治疗治疗治疗治疗治疗治疗更多相关视频
06:51Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
12.6K
09:12A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
10.2K
相关概念视频
Development of Antibiotic Resistance
38
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
38
Antimicrobial Effectiveness
44
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
44
Antibiotic Selection
54.7K
Overview
54.7K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
157
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
157
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
