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99mTc-HFAPi成像识别了高血压心脏的早期心肌纤维化

Boqia Xie¹, Lina Li², Mingming Lin³

¹Department of Cardiology, Cardiovascular Imaging Center.

Journal of hypertension

|August 29, 2023

概括

在结构变化发生之前,99mTc-HFAPi成像检测高血压的早期心肌纤维化. 这种纤维细胞激活蛋白抑制剂成像显示了在高血压心脏中识别纤维生成的前景.

科学领域:

心脏病学心脏病学
核医学就是核医学.
生物医学成像技术生物医学成像技术

背景情况:

高血压与心肌纤维化有关,心脏功能障碍的关键因素.
早期发现心肌纤维化对于及时干预高血压心脏病至关重要.

研究的目的:

评估99mTc放射标记纤维细胞激活蛋白抑制剂 (99mTc-HFAPi) 成像在高血压中检测早期心肌纤维化中的疗效.
调查99mTc-HFAPi吸收是否在高血压心脏中的结构和功能变化之前.

主要方法:

使用自发高血压大鼠 (SHRs) 和Wistar京都大鼠 (WKYs) 进行临床前研究,包括99mTc-HFAPi成像,心声学和组织学分析.
评估纤维细胞激活蛋白 (FAP) 和 I 原表达通过定量PCR和西部涂抹.
进行了一项临床研究,涉及106名高血压患者和20名健康对照人,接受99mTc-HFAPi成像和心声扫描.

主要成果:

在SHR心脏中,99mTc-HFAPi的吸收量从第8周开始,在原沉积之前 (在第28周检测到) 升高.
从第8周开始,SHRs中的FAP表达增加,而 I原水平直到第28周保持不变.
在高血压患者中,即使在正常的透析功能,几何学和全球纵向应变的情况下,也观察到99mTc-HFAPi吸收增加,这表明早期纤维化.

结论:

99mTc-HFAPi成像可以识别高血压心脏中的早期纤维化过程.
这种成像模式在显著的结构或功能异常出现之前就能检测到心肌纤维化,为早期诊断和管理提供了潜力.

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