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与中风相关的内脏变化:基于voxel的神经解剖学定位研究

Ethem Murat Arsava¹, Ken Chang^1,2, Ahmed Tawakol³

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

Annals of neurology

|August 29, 2023

概括

脑梗塞的位置与中风后的特定心脏和系统异常 (CSA) 有关. 识别这些神经解剖学相关性可以帮助区分中风的原因并改善患者的治疗结果.

科学领域:

神经科学是一个神经科学.
心脏病学心脏病学
内部医学内部医学

背景情况:

脑外器官的变化可以跟随急性脑损伤,但它们的特定脑相关性尚未完全理解.
心脏和全身异常 (CSAs) 在中风后很常见,但精确的神经解剖起源仍然不清楚.

研究的目的:

调查脑梗塞与特定的心脏和全身异常 (CSAs) 相关的假设,以区域依赖的方式.
确定中风后CSAs的神经解剖相关物,包括心脏中素T升高,QTc延长,急性压力高血糖症和感染.

主要方法:

在1208名急性缺血性中风患者中,分析了脑梗塞的voxelwise p值图.
使用基于 permutation 的方法,检查了心脏病发作位置和 CSA (心脏热素 T, QTc 延长,急性压力高血糖症,感染) 之间的关系.
与CSA相关的显著,空间分离的voxel集群的识别.

主要成果:

对于每一个CSA,都确定了明显的,空间分离的voxel集群.
热素升高和QTc延长群主要位于右半球.
急性压力高血糖症集群主要在左半球,而感染集群 (肺炎,尿道感染) 在两半球都被发现.
在对心脏病发作量进行调整后,心脏病发作位置和CSA之间的关联仍然显著.

结论:

离散的脑梗塞区域与不同的CSA特别相关.
这些发现可能有助于开发新的标志物,以区分神经性和非神经性原因的中风后CSAs.
了解这些区域性脑体相互作用对于优化中风护理和管理至关重要.

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