循环维生素D度和14种癌症的风险:一个双向的门德尔随机化研究
Yuxuan Dai1, Yu Chen2, Yifu Pu3
1Department of Plastic Surgery, The Third Bethune Hospital of Jilin University, Changchun, 130000, China.
Journal of cancer research and clinical oncology
|August 29, 2023
概括
这项研究发现,维生素D水平可能会因果关系地影响黑色素瘤皮肤癌风险. 反向分析还表明,维生素D与结直肠癌之间存在联系,这凸显了维生素D在预防癌症方面的重要性.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,维生素D水平与癌症风险之间存在联系,但因果关系仍有争议.
- 研究维生素D在各种癌症中的因果作用对于了解疾病机制和预防策略至关重要.
研究的目的:
- 确定循环维生素D度与14种不同类型癌症的风险之间的因果关系.
- 利用门德尔的随机化来评估潜在的因果关系,解决观察数据的局限性.
主要方法:
- 采用两个样本的孟德尔随机化 (MR),使用全基因组关联研究总结统计数据对14种癌症.
- 使用逆变量权衡 (IVW) 作为主要分析,使用MR-Egger,加权中位数,加权模式和简单模式进行验证.
- 进行多次敏感性分析以确保调查结果的稳定性和可靠性.
主要成果:
- 没有发现维生素D水平与研究的大多数癌症之间存在显著的因果关系.
- 在维生素D度和黑色素瘤皮肤癌 (MSC) 风险之间发现了积极的因果关系.
- 反向MR分析表明,维生素D水平与结直肠癌风险降低之间存在潜在的因果关系.
结论:
- 研究结果支持维生素D在黑色素瘤皮肤癌的发展中起因作用.
- 有证据表明,维生素D可能在结直肠癌预后中起作用,这需要进一步调查.
- 强调了维生素D在治疗多发性结肠癌和潜在影响结肠直肠癌结果方面的重要性.
更多相关视频
06:43A Quantitative Assay to Study Protein:DNA Interactions, Discover Transcriptional Regulators of Gene Expression, and Identify Novel Anti-tumor Agents
Published on: August 31, 2013
18.8K
08:12Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
5.5K
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Role of Skin in Vitamin D Synthesis
5.3K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.3K
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Positive Regulator Molecules
5.5K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.5K
Connective Tissue Cell Types
3.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.3K
