在Hirschsprung疾病的新生儿患者中,经过单阶段的透过内直肠拉透后,长期的肠功能
Zhaozhou Liu1, Yanan Zhang1, Shuangshuang Li1
1Department of Neonatal Surgery, Beijing Children Hospital, Capital Medical University, National Center for Children's Health, 56 Nanlishi Road, Beijing, 100045, China.
Pediatric surgery international
|August 29, 2023
概括
大多数新生儿赫施普朗格病 (HD) 患者接受过门内肠透 (TEPT) 治疗,取得了良好的长期结果. 长段性角膜炎和延长的住院时间与TEPT手术后肠道功能较差有关.
科学领域:
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
- 临床结果研究研究
背景情况:
- 赫施普隆病 (Hirschsprung disease,简称HD) 是一种影响大肠的先天性疾病.
- 新生儿手术正通常涉及过内肠直肠拉透 (TEPT).
- 长期的功能结果和低于正常的肠功能预测因素需要进一步调查.
研究的目的:
- 评估新生儿HD患者单阶段TEPT的长期结果.
- 为了确定TEPT后的低最佳肠功能预测因素.
主要方法:
- 160名接受新生儿TEPT (2007-2019) 的HD患者的回顾性分析.
- 使用肠功能评分 (BFS) 问卷对长期肠功能进行评估.
- 在正常和不正常BFS (BFS<17) 的患者之间比较临床变量.
- 后勤回归分析以确定不正常BFS的独立风险因素.
主要成果:
- 平均随访时间为7.3年.
- 83.8%的患者有正常的肠功能 (BFS ≥17).
- 不正常BFS的独立风险因素包括长段或全结肠腺瘤 (OR 3.213) 和术后住院时间>8.5天 (OR 3.813).
结论:
- 新生儿期的单阶段TEPT通常为HD患者带来有利的长期结果.
- 长段/全结肠角膜炎和术后长时间住院与不正常肠功能风险增加有关.
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