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一项基于风险的肺癌查试点研究的结果:结果和与符合Medicare资格的队列对比

Erin A Hirsch¹, Melissa L New^2,3, Stephanie L Brown⁴

¹Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12700 E 19th Ave, Aurora, CO, 80045, USA. Erin.Hirsch@cuanschutz.edu.

Discover oncology

|August 29, 2023

概括

使用PLCOm2012模型的基于风险的肺癌查识别了与传统查标准相似的候选人. 这种方法在不同患者群体中对早期肺癌检测有希望.

科学领域:

肺部病理学肺部病理学
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

肺癌查指南传统上依赖于年龄和吸烟史.
基于风险的查模型,如PLCOm2012,为识别高风险个体提供了更个性化的方法.
基于风险的肺癌查在美国的广泛实施和评估是有限的.

研究的目的:

使用PLCOm2012风险模型前性地确定患者进行肺癌查.
为了比较基于风险的确诊患者的特征,风险概况和查结果,与传统的合格队列进行比较.
评估基于风险的肺癌查在临床环境中的可行性.

主要方法:

招募了具有6年肺癌风险评分≥1.5% (PLCOm2012) 的参与者,根据2015年医疗保险指南,他们不符合条件.
在知情同意后进行共享决策咨询和低剂量CT (LDCT) 查.
通过使用适当的统计测试,将研究人口的特征和结果与符合Medicare资格的队列进行比较.

主要成果:

在2016年8月至2019年7月期间,完成了48个基线LDCT.
10%的最不发达国家建议进一步评估结节 (肺-RADS 3或4).
在15年前戒烟的前吸烟者中诊断出两种早期肺癌. 研究队列比医疗保险队列年龄大,包装年数较低.

结论:

基于风险的前性选确定了与传统符合条件的队列相比的候选人.
需要进一步的研究来评估风险计算器对肺癌结果的影响.
优化基于风险的查工具的临床可用性对于更广泛的采用至关重要.

关键词:

癌症查癌症查肺癌是一种肺癌.肺癌查肺癌查肺癌查基于风险的查是基于风险的查.

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