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卵巢反应较差的女性的基因表达和人口分析:一种计算方法

Nastaran Bahrami¹, Arnoosh Nazari¹, Zahra Afshari¹

¹Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Journal of assisted reproduction and genetics

|August 29, 2023

概括

人口特征,而不是基因表达,从对照组中区分了卵巢反应差 (POR) 的女性. 这表明人口因素可能会影响卵细胞成熟中的基因表达.

科学领域:

生殖生物学生殖生物学
遗传学遗传学是一个
不孕症的研究研究.

背景情况:

卵巢反应 (POR) 较差的特征是卵泡发育减少和刺激后雌激素水平较低.
卵细胞成熟涉及许多基因,其能力可能受到人口和生活方式因素的影响.

研究的目的:

为了比较POR妇女和健康对照者的基因表达和生活习惯.
为了研究特定基因 (FIGLA,ZAR1,WNT4,LHX8,APC,H1FOO,MOS,DMC1) 在POR女性粒状细胞中的作用.

主要方法:

使用定量PCR测量50名女性的基因表达 (25名POR,25名对照).
统计分析包括线性差异分析 (LDA),冗余分析 (RDA) 和隐性因子混合模型 (LFMM).

主要成果:

两组之间研究的基因表达没有发现显著差异.
LDA,RDA和LFMM没有根据基因表达或地理变量区分群体.
人口特征的LDA成功地区分了POR和对照组.

结论:

人口特征,而不是研究的基因表达水平,似乎是POR和对照女性之间的关键差异化因素.
人口因素可能会显著影响与卵细胞质量相关的基因表达模式.

关键词:

基因表达特征基因表达特征在 LFMMMM 中.生活方式生活方式卵巢卵巢卵巢卵巢

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