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在组织工程中 Orofacial MSCs 的潜在应用周围神经损伤修复神经指导的组织工程神经指导

Qingyu Meng¹, Justin C Burrell¹, Qunzhou Zhang²

¹Department of Oral & Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, 240 South 40Th Street, Philadelphia, PA, 19104, USA.

Stem cell reviews and reports

|August 29, 2023

概括

周围神经修复 (PNR) 是一个挑战. 面膜介质干细胞 (MSCs) 在组织工程神经引导管道中增强神经再生的潜力,特别是在大隙间.

科学领域:

生物材料科学生物材料科学
干细胞生物学干细胞生物学
再生医学是一种再生医学.

背景情况:

周围神经损伤 (PNI) 会导致显著的感觉和运动功能丧失.
目前的修复方法,如和移植,具有局限性,包括神经紧张,捐赠部位的发病率和免疫性.
大间隙神经损伤 (≥3厘米) 仍然难以有效地治疗现有的神经引导管道 (NGC).

研究的目的:

审查外围神经损伤的病理生理学.
探索口面介质干细胞 (MSCs) 的特性和功能.
突出使用口面MSCs在组织工程NGC中用于外围神经修复 (PNR).

主要方法:

关于PNI病理生理学的文献综述.
分析表面或表面的MSC特征和生物作用.
检查使用NGC中面膜MSC进行PNR的临床前研究.

主要成果:

来自神经细胞的面膜MSCs,由于可访问性和生物特性,为PNR提供了独特的优势.
结合MSC与先进生物材料的组织工程方法正在改善NGC.
临床前模型表明,面膜MSC装载NGC可增强神经再生的潜力.

结论:

面膜MSCs是开发下一代NGC的有希望的细胞来源.
进一步研究面膜MSC可以克服PNR当前的局限性,特别是大神经间隙.
干细胞生物学和生物材料科学的整合对于推进PNR治疗至关重要.

关键词:

神经指导管道的神经指导管道神经峰的神经峰神经组织工程神经组织工程面膜介质干细胞或面膜介质干细胞.周围神经的再生和再生

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