慢性心力衰竭患者中红细胞分布宽度的预后影响 患有左心室功能障碍的患者
Ana Isabel Ferreira1, João Enes Silva1, Nuno Melo1
1Internal Medicine Department, Centro Hospitalar Universitário de São João.
Journal of cardiovascular medicine (Hagerstown, Md.)
|August 29, 2023
概括
慢性心力衰竭 (HF) 患者红细胞分布宽度 (RDW) 的增加与死亡率的增加有关. 较高的RDW值,特别是超过14.7%,显著预测HF患者的长期预后会更差.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 红细胞分布宽度 (RDW) 量化了红细胞大小的变化.
- 增加的RDW与急性心力衰竭 (HF) 的不良结果有关.
- 慢性HF中RDW的预后意义需要进一步调查.
研究的目的:
- 评估RDW对慢性心力衰竭患者全因死亡率的预后影响.
- 确定 RDW 是否可以作为慢性高频率的长期结果的预测生物标志物.
主要方法:
- 追溯分析了860名慢性HF患者的左心室缩功能障碍.
- 被归类为RDW第三类的患者:≤13.5%,13.5-14.7%,和>14.7%.
- 考克斯回归分析用于评估RDW与所有原因死亡率之间的关联,平均随访时间为49个月.
主要成果:
- 死亡率逐渐增加,随着较高的RDW第三种动物.
- 与RDW>14.7%的患者相比,与RDW ≤13.5%的患者相比,所有原因死亡率 (HR 1.81-1.95) 的风险增加了近2倍.
- 第二个RDW第三组 (13.5-14.7%) 的患者也显示出明显更高的死亡风险 (HR 1.44-1.47).
结论:
- RDW是一个有价值的,易于获取的参数,用于慢性HF的风险分层.
- 患有RDW>14.7%的慢性HF患者面临着更高的长期死亡风险.
- RDW可以帮助临床医生识别慢性HF人群中的高风险个体.
更多相关视频
04:05Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
Published on: June 30, 2023
1.9K
06:39Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
15.0K
相关概念视频
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:29Heart Failure II: Pathophysiology
15
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15
01:26Heart Failure III: Clinical Manifestations
23
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
23
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
12
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
12
01:20Mitral Regurgitation I: Introduction
16
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
16
01:30Heart Failure IV: Classification and Diagnostic Evaluation
19
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
19