NDUFB11和NDUFS3在动脉样硬化和慢性压力中起作用
Yin Yang1, Jing-Hui Li1, Bo-Chen Yao1
1Clinical School of Thoracic, Tianjin Medical University, Tianjin Chest Hospital, Jinnan, Tianjin 300222, P.R. China.
Aging
|August 29, 2023
概括
在动脉样硬化和慢性压力中,NDUFB11和NDUFS3的表达不足. 这些基因的较低水平与更糟糕的预后相关,这表明它们在疾病进展中的作用.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 压力生理学 压力生理学
背景情况:
- 动脉样硬化涉及动脉斑块的形成,导致血管狭窄.
- 慢性压力是一种长期的压力状态,与动脉样硬化的联系不清楚.
- 在这种情况下,NDUFB11和NDUFS3的作用尚不清楚.
研究的目的:
- 研究NDUFB11,NDUFS3,动脉样硬化和慢性压力之间的关系.
- 在出现慢性压力时,确定动脉样硬化背后的分子机制.
主要方法:
- 差异表达基因 (DEGs) 的查和权重基因联合表达网络分析 (WGCNA).
- 构建和分析蛋白与蛋白相互作用 (PPI) 网络.
- 功能性丰富分析 (GO,KEGG),基因组丰富分析 (GSEA),基因表达热图,免疫透,mRNA分析和西斑 (WB).
主要成果:
- 确定了1708种DEG,它们在代谢途径中富含.
- 在慢性压力性动脉样硬化中,NDUFB11和NDUFS3显著表达不充分.
- 较低的NDUFB11和NDUFS3表达与炎症和认知障碍等相关疾病的严重程度增加相关.
结论:
- 在动脉样硬化和慢性压力中,NDUFB11和NDUFS3的表达不足.
- 减少的NDUFB11和NDUFS3水平表明预后较差.
- 这些基因可能作为动脉样硬化和慢性压力的潜在生物标志物.
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