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Updated: Jul 17, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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抑制EEF2的毒素会激活NLRP1炎症体,并促进表皮屏障的破坏

Miriam Pinilla1, Raoul Mazars1, Romain Vergé1

  • 1Institute of Pharmacology and Structural Biology , University of Toulouse, CNRS , Toulouse, France.

The Journal of experimental medicine
|August 29, 2023
PubMed
概括

Pseudomonas aeruginosa 的外毒素A 通过 riboylating eukaryotic 延伸因子2 (EEF2) 激活NLRP1炎症体,从而引起核糖毒性压力. ZAKα 激酶抑制剂可以阻断囊性纤维化细胞中的这种炎症酶激活.

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