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在长期护理设施中对SARS-CoV-2的废水监测:混合方法评估

James W Keck¹, Jess Lindner², Matthew Liversedge³

¹Department of Family & Community Medicine, University of Kentucky, Lexington, KY, United States.

JMIR public health and surveillance

|August 29, 2023

概括

肯塔基州长期护理设施 (LTCF) 的废水监测显示,在早期检测COVID-19方面表现不一. 虽然可行,但数据解释和及时性方面的挑战需要关注弱势群体.

科学领域:

公共卫生监督公共卫生监督
环境病毒学环境病毒学
传染病流行病学传染病流行病学

背景情况:

废水监测为社区提供了早期COVID-19检测.
长期护理设施 (LTCF) 面临着高的COVID-19发病率和死亡率.
在肯塔基州的6个LTCF中实施了楼层废水监测,以预警.

研究的目的:

评估肯塔基州LTCF的SARS-CoV-2废水监测的表现.
评估系统属性,包括简单性,灵活性,数据质量,敏感性,PPV,及时性,代表性和稳定性.

主要方法:

混合方法评估遵循了CDC对公共卫生监测系统的指导方针.
对利益相关者进行了半结构化的采访,并进行了主题内容分析.
废水,临床测试和工艺数据被整合在一起,以评估性能属性.

主要成果:

废水监测需要适度的资源和技术能力.
该系统在调整频率和检测其他病原体方面表现出灵活性.
使用临床测试作为黄金标准,灵敏度为30.6%,特异性为79.7%;PPV在>0副本/毫升时为34.8%.
在元数据 (3.53%) 和PCR (1.81%) 中发现了数据质量问题.
由于缺乏周末实验室人员,及时性受到影响,数据在收集后24-72小时内收到.
代表性挑战包括外部废物来源和居民因素.
稳定性成本大约为每家设施每天144.50美元.

结论:

根据CDC的标准,LTCF废水监测系统的表现不一.
利益相关者认为监控是可行的,但在数据解释和可操作性方面存在挑战.
人们对其在保护弱势LTCF群体方面的潜力持乐观态度.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.评价评价评价评价长期护理机构的长期护理设施.废水监管监督废水的情况.基于废水的流行病学.

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