商业平台的结果与疫苗接种后的SARS-CoV-2中和抗体反应和临床宿主因素的相关性
Rebecca Slotkin1, Tassos C Kyriakides1,2,3, Anupam Kundu2,3
1Yale School of Medicine, New Haven, Connecticut, United States of America.
PloS one
|August 29, 2023
概括
在SARS-CoV-2疫苗接种后的IgG抗S1/RBD和中和抗体 (nAb) 之间存在强烈的相关性. 之前的COVID-19感染和功能显著影响了这种关系,有助于免疫保护预测.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 评估疫苗接种后对SARS-CoV-2的免疫力至关重要.
- 商业上可用的IgG抗S1/RBD抗体检测方法被广泛使用.
- 了解这些测定和保护性中和抗体 (nAb) 之间的相关性对于临床应用很重要.
研究的目的:
- 确定成年人接种疫苗后IgG抗S1/RBD水平和血清nAb与SARS-CoV-2之间的相关性.
- 调查临床变量对这种相关性的影响.
主要方法:
- 来自接种疫苗的个体的血清进行了针对SARS-CoV-2 WA-1的IgG抗S1/RBD和nAb IC50的测试.
- 使用皮尔森相关性来评估IgG和IC50.5之间的关系.
- 收集了临床变量,并使用单变量和多变量回归分析了它们对IgG-nAb相关性的影响.
主要成果:
- 在IgG抗S1/RBD和nAb IC50.0之间发现了强烈的相关性 (R2 = 0.83).
- 之前的COVID-19感染和估计的膜过率 (GFR) 显著影响了相关性.
- 年龄和性别呈现显著性趋势,但在多变量分析中没有显著性.
结论:
- 在SARS-CoV-2疫苗接种后,IgG抗S1/RBD和nAb IC50之间存在强烈的相关性.
- 临床因素,如先前感染和功能影响这种相关性.
- 这些发现支持使用商业平台来预测疫苗接种后的免疫保护.
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