大麻的药理动力学:系统性审查和元回归分析
Ehsan Moazen-Zadeh1,2, Alexandra Chisholm1,2,3, Keren Bachi1,2,4
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Cannabis and cannabinoid research
|August 29, 2023
概括
本综述详细介绍了大麻 (CBD) 的剂量,施用途径和饮食如何影响其药理动力学 (PK). 口服CBD提供更高的生物可用性,而纳米技术配方提供更快的开始,影响临床应用.
科学领域:
- 药理动力学和药物新陈代谢
- 大麻素科学 大麻素科学
- 临床药理学 临床药理学
背景情况:
- Cannabidiol (CBD) 被广泛研究,但其药理动力学 (PK) 变异性需要全面了解影响因素.
- 关于CBD药理动学的现有证据需要进行最新的评估,特别是关于剂量,服用途径和配方.
- 本次审查解决了关于各种因素如何影响CBD的吸收,分布,新陈代谢和分泌 (ADME) 概况的需要.
研究的目的:
- 为健康成年人提供关于大麻 (CBD) 的药理动力学 (PK) 现有证据的最新评估.
- 探索不同因素,包括剂量,服用途径,配方和饮食,对CBD PK结果的影响.
- 通过阐明CBD生物可用性和PK变异性的关键决定因素,为药物开发和临床实践提供信息.
主要方法:
- 在血清或血中报告CBD PK参数 (Tmax,Cmax,AUC,T1/2) 的试验的系统审查和元回归分析.
- 在Medline,Embase,PsycInfo和Web of Science核心集合中搜索到2022年11月19日;不包括患者群体和联合管理.
- 利用NHLBI质量评估工具,对来自39项研究的112个试验臂进行随机效应多变量元回归分析.
主要成果:
- 较高的CBD剂量与增加的Cmax,AUC0-t和AUC0-inf.相关.
- 与口服药物相比,口服药物给药导致较低的Cmax,AUC0-t和AUC0-inf.
- 美联储状态增加了Cmax和AUC0-t与禁食状态相比;较高的女性参与者比例与较低的Tmax和较高的Cmax有关.
结论:
- CBD剂量,服用途径 (通过口服产生更高的生物可用性) 和饮食是CBD药理学的主要决定因素.
- 纳米技术配方表明CBD的作用开始更快.
- 虽然初步数据表明女性的发病速度更快,持续时间更长,但需要进一步的研究来确认CBD PK中生物性别的作用.
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