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Updated: Jul 17, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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在怀孕期间使用线索利德的安全性

Sabrina Navarro1, Kori Keith, Chrysovalantis Stafylis

  • 1From the Department of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA.

Sexually transmitted diseases
|August 29, 2023
PubMed
概括

由于流行病的增加和青素短缺,正在探索替代性梅毒治疗方法. 莱涅佐利德显示出有前途的结果,在一项审查中没有观察到致病性影响,尽管动物研究发现了一些不良事件.

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Teratogenicity01:07

Teratogenicity

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The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
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