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相关概念视频

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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What is the Immune System?01:38

What is the Immune System?

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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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相关实验视频

Updated: Jul 17, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
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An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

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肠道免疫微环境和自身免疫

Qiaolin Wang1, Qianjin Lu1, Sujie Jia2

  • 1Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing 210042, China.

International immunopharmacology
|August 29, 2023
PubMed
概括

肠道微生物群和肠道免疫微环境对于保持健康至关重要. 失生症会破坏这种平衡,导致自身免疫性疾病和肠外疾病.

关键词:
这是一种自身免疫力.这是一个很棒的体验,Gut Gut Gut Gut.与肠道相关的淋巴组织.免疫细胞是免疫细胞.肠道内皮细胞内淋巴细胞.

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
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Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

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相关实验视频

Last Updated: Jul 17, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
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An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
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科学领域:

  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学
  • 胃肠病学 胃肠病学

背景情况:

  • 肠道内有复杂的免疫微环境,对恒常状态至关重要.
  • 肠道微生物群与免疫细胞相互作用,维持肠道免疫平衡.
  • 肠道微生物群的不平衡与免疫调节失调有关.

研究的目的:

  • 审查肠道免疫微环境的组成.
  • 探索肠道免疫微环境与自身免疫之间的关联.
  • 为自身免疫性疾病的发病和治疗提供洞察力.

主要方法:

  • 关于肠道免疫和微生物群的现有研究的文献综述.
  • 分析肠道免疫微环境在自身免疫性疾病中的作用.
  • 讨论将肠道失调与肠外自身免疫联系在一起的机制.

主要成果:

  • 肠道微生物群的失调破坏了免疫系统的平衡.
  • 肠道免疫微环境的不平衡与自身免疫性疾病有关.
  • 炎症细胞从肠道迁移可以引发肠外自身免疫疾病.

结论:

  • 肠道免疫微环境和微生物群在自身免疫性中至关重要.
  • 了解这些相互作用为自身免疫疾病提供了新的治疗策略.
  • 准肠道微生物群可以预防和治疗自身免疫性疾病.