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生产CHOPe003-A ESC线来研究影响光滑肌肉发育和功能的ACTG2变体

Sohaib K Hashmi1, Sabine Schneider2, Alyssa L Gagne3

  • 1Department of Pediatrics, The Children's Hospital of Philadelphia Research Institute, Abramson Research Center, 3615 Civic Center Blvd, Philadelphia, PA 19104, United States; Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States; Department of Bioengineering, The University of Pennsylvania School of Engineering and Applied Science, 220 S 33rd St, Philadelphia, PA 19104, United States; Department of Internal Medicine, Hospital of the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States.

Stem cell research
|August 29, 2023
PubMed
概括

玛光滑肌动蛋白 (ACTG2) 的遗传突变会导致内脏肌病,这是一种严重的疾病,影响肠道,膀和子宫功能. 研究人员创建了一个人类干细胞模型来研究这种ACTG2 R257C突变对光滑肌肉的影响.

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