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响应CO2的深度浸泡溶剂,用于从肥沃的皮中提取hesperidin

Shanshan Wang¹, Tian Lei², Leilei Liu³

¹Key Laboratory of Hunan Forest Products and Chemical Industry Engineering, National and Local United Engineering Laboratory of Integrative Utilization of Eucommia Ulmoides, Jishou University, Zhangjiajie 427000, China.

|August 29, 2023

概括

研究人员开发了一种新型的二氧化碳反应敏捷的深溶解剂 (DES),用于有效地从皮中提取hesperidin. 这种可回收的溶剂系统显著改善了西的回收,并提供了一种可持续的方法来分离生物活性化合物.

科学领域:

绿色化学绿色化学
自然产品提取提取自然产品
溶剂工程溶剂工程

背景情况:

素是一种具有重要的工业潜力的黄类化合物,传统上使用常规溶剂提取.
开发可持续和高效的提取方法对于自然产品的隔离至关重要.
深度乙溶剂 (DESs) 具有可调节的特性和可回收性,使其成为有前途的替代品.

研究的目的:

为了研究二氧化碳敏感的DES作为皮色素的可回收提取剂.
为了优化提取条件以最大限度地提高hesperidin产量.
通过计算方法探索hesperidin提取的机制.

主要方法:

利用CO2/N2泡来诱导DES溶液中的可逆相变.
优化的参数包括DES组成,含水量,固体-液体比,温度和超声波时间.
使用密度功能理论 (DFT) 来分析影响提取的分子间相互作用.

主要成果:

使用特定的DES (三甲胺:4-甲基,1:1) 实现了hesperidin 22.39 mg/g的最大提取产量.
在二氧化碳处理后的顶部阶段恢复了hesperidin的74.38%,证明了有效的分离.
提取产量明显超过了用甲醇获得的产量.

结论:

对二氧化碳有反应的DES是hesperidin的有效和可循环提取剂.
该研究提出了一种可持续的方法,用于从自然来源中分离生物活性化合物.
根据DFT分析,和π-π键在hesperidin提取中发挥着关键作用.

关键词:

生物活性化合物生物活性化合物具有对CO2反应的深层环氧溶剂.提取提取提取赫斯佩里迪因是人类的一种药物.可回收利用的提取剂可以回收利用.

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