在患有动脉疾病的患者中,V因子莱登,前激素,MTHFR和PAI-1基因多态化:全面的系统审查和元分析
Emanuele Valeriani1, Daniele Pastori2, Giulia Astorri2
1Department of General Surgery and Surgical Specialty, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy; Department of Infectious Disease, Umberto I Hospital, Viale del Policlinico 155, Rome, Italy.
Thrombosis research
|August 29, 2023
概括
遗传性血栓,血栓的遗传性倾向,在患有动脉疾病的患者中比较常见,如中风,心脏病发作和外周动脉疾病. 测试可能对某些患者群体有益.
科学领域:
- 心血管遗传学 心血管遗传学
- 血栓形成研究研究
- 分子流行病学分子流行病学
背景情况:
- 遗传性血栓友病和动脉疾病之间的关联仍然不清楚.
- 这项研究系统地审查和元分析了脑血管疾病 (CVD),冠状动脉疾病 (CHD) 和外周动脉疾病 (PAD) 的患者遗传性血栓性病的患病率.
研究的目的:
- 确定CVD,CHD和PAD患者中特定遗传性血栓性基因多态性的综合流行率和概率比率.
- 为了确定遗传性血栓友病和动脉疾病风险之间的潜在关联.
主要方法:
- 一项系统性审查和对2022年2月之前发表的研究进行元分析.
- 在MEDLINE和EMBASE数据库中进行了搜索.
- 评估的因子V莱登 (G1691A),前热血素 (G20210A),MTHFR (C677T/A1298C) 和PAI-1 (4G/5G) 基因多态.
- 使用随机效应模型计算聚合流行率 (PPs) 和赔率比率 (ORs).
主要成果:
- 包括377项研究,涉及98,186名患者和108,569名对照.
- 与对照人群相比,在心血管疾病,心血管疾病和PAD患者中发现血栓友爱症的综合流行率增加.
- 确定了某些多形态的显著概率比率,特别是CVD中的同卵性V因子Leiden (G1691A) 和前血栓 (G20210A),以及PAD中的PAI-1 4G/4G.
- 根据年龄和地理区域观察到的患病率和几率比率的变化.
结论:
- 患有动脉疾病的患者表现出更高的患病率和某些遗传性血栓塞病的几率.
- 对特定的患者亚组,特别是那些有强烈的家族病史或来自患病率较高的地区,可能需要考虑进行血栓友测试.
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