多个精神病多基因风险评分预测了童年逆境和双相情感障碍之间的关联
Kai Yao1, Tracey van der Veen1, Johan Thygesen2
1Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
Journal of affective disorders
|August 29, 2023
概括
双极性障碍 (BD) 的不良童年经历 (ACE) 和多基因风险评分 (PRS) 影响结果. 虽然ACE与BD早期发病和快速循环相关,而BD PRS与精神病症状相关,但没有发现基因与环境的相互作用.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 环境健康 环境健康
背景情况:
- 儿童不良经历 (ACE) 和双相情感障碍 (BD) 的遗传倾向在症状轨迹上的相互作用仍然不太清楚.
- 研究基因与环境的相互作用对于理解BD病原和结果至关重要.
研究的目的:
- 检查精神疾病ACE和多基因风险评分 (PRS) 如何相互作用影响BD症状结果.
- 评估ACE,各种精神病PRS和特定的BD亚现象类型之间的关联.
主要方法:
- 用计算的BD,ADHD,MDD和SCZPRS对885名BD受试者的分析.
- 使用儿童生活事件问卷 (CLEQ) 评估ACE.
- 应用多重线性和逻辑回归来评估ACE和PRS之间的关联和相互作用.
主要成果:
- 增加的ACE与较高的ADHD PRS相关.
- 患有ACE的BD患者经历了更早的发病和更高的快速循环的几率.
- 较高的BD PRS预测精神病症状的几率增加,较高的ADHD PRS预测快速循环.
- 没有观察到MDD或SCZ PRS的显著预测效应,也没有观察到ACE和PRS之间的显著相互作用.
结论:
- 这些发现强调了在预测BD患者的症状结果时考虑多个精神病学PRS的重要性.
- 该研究强调了ACE,ADHD PRS和BD亚表型之间的特定关联,尽管没有检测到直接的基因环境相互作用.
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