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内分泌大麻素系统和跨动物物种的侵略性

Martin Migliaro¹, Alejandra E Ruiz-Contreras², Andrea Herrera-Solís³

¹Grupo de Neurociencias: Laboratorio de Cannabinoides, Departamento de Fisiología, Facultad de Medicina, UNAM, Mexico.

Neuroscience and biobehavioral reviews

|August 29, 2023

概括

内分泌大麻素系统 (ECS) 在调节侵略性方面发挥着关键作用. 增强ECS信号传输,特别是通过大麻素受体1型,可以减少动物的攻击性行为.

科学领域:

神经科学是一个神经科学.
行为生物学行为生物学
药理学药理学是指药理学的学科.

背景情况:

内激素系统 (ECS) 是一个复杂的细胞信号系统,参与调节各种生理过程.
侵略是脊椎动物种类中观察到的基本行为,对社会动态和福祉有重大影响.
了解侵略的神经生物学基础对于开发有针对性的干预措施至关重要.

研究的目的:

审查和综合当前关于内分泌大麻素系统 (ECS) 与脊椎动物攻击性行为之间的关系的研究.
为了检查植物性大麻素,合成大麻素和内分泌大麻素对侵略信号的调节的影响.
确定大麻素受体,特别是大麻素受体1型 (CB1) 在调节侵略性行为的作用.

主要方法:

这项研究是对现有实验和临床前研究的叙述性审查.
文献搜索侧重于研究大麻素和ECS调制对动物模型中的侵略影响的研究.
分析与急性和慢性注射大麻素及其对侵略行为的影响相关的研究结果.

主要成果:

植物性大麻素,合成大麻素和增强的内分泌大麻素信号的急性施用在多种动物模型中持续减少了攻击性行为.
对大麻素对侵略性的慢性影响的研究产生了不一致的结果,突出了需要进一步调查的需要.
大麻素受体,特别是CB1,被确定为抑制侵略行为的内源性机制的重要组成部分.

结论:

内分泌大麻素系统 (ECS) 是脊椎动物物种中侵略性行为的关键调节者.
准ECS,特别是CB1受体,显示出对控制侵略的治疗潜力.
需要进一步的研究来阐明大麻素对侵略的慢性影响,并完善潜在的治疗策略.

关键词:

攻击性侵略性攻击性动物研究动物研究这是一个CB1受体.内分泌大麻素系统内分泌大麻素系统神经生物学神经生物学神经生物学这是一种植物性大麻素 (phytocannabinoid).社会主导地位社会主导地位社会上的依从性社会上的依从性.

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