大脑网络结构连接体异常在青少年与注意力缺陷/多动障碍在变化的双相I型障碍的风险:一个横截面图基于磁共振成像研究研究注意力缺陷/多动症:一个横截面图基于磁共振成像研究
1From the Huaxi MR Research Center (HMRRC), Department of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China (Zhu, Qin, X. Li, Gong); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH (Zhu, Qin, Tallman, Patino, Fleck, Aghera, Sweeney, McNamara, DelBello); the College of Medical Informatics, Chongqing Medical University, Chongqing, China (Lei); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (X. Li); the Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (W. Li); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gong); the Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian, China (Gong).
患有注意力缺陷/多动障碍 (ADHD) 的青少年表现出常见的大脑网络差异. 对双极性疾病 (BD-I) 的家族风险与明显的突出网络变化有关,可能表明BD-I的早期迹象.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 注意缺陷/多动障碍 (ADHD) 常见于患有或有双相I型障碍 (BD-I) 风险的年轻人.
- ADHD 症状往往先于 BD-I,可能会增加其风险.
- 关联ADHD和家族BD-I风险的神经病理生理机制尚不清楚.
研究的目的:
- 在患有ADHD的青少年中研究大脑结构网络拓学.
- 检查具有或没有家族BD-I风险的ADHD年轻人之间的差异.
- 识别ADHD中BD-I风险的潜在神经标记物.
主要方法:
- 对149名年轻人 (10-18岁) 的横截面研究,分为三个组:健康对照组,ADHD (低BD-I风险) 和ADHD (高BD-I风险).
- 基于图形的结构MRI数据的网络分析,以评估大脑网络拓.
- 与ADHD和情绪症状评级相关联的网络指标.
主要成果:
- ADHD组 (低风险和高风险) 与对照组表现出类似的大脑网络差异,特别是在默认模式和中央执行网络中.
- 与低风险和对照组相比,高风险的ADHD青年在突出网络中表现出独特的变化.
- 全球网络异常仅在高风险ADHD组和对照组中显著. 右下额头回环指标与ADHD症状严重程度相关.
结论:
- 患有多动症的年轻人,无论家族BD-I风险如何,都有共同的脑连接体异常.
- 高风险多动症青少年的突出网络拓的改变可能是BD-I的一个突发性特征.
- 需要进一步的研究来确定这些发现与BD-I风险进展的相关性.
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