一个简单,轻量级和低成本的可定制的多电极阵列,用于本地场潜在记录
Richard Quansah Amissah1, Abdalla M Albeely2, Elise M Bragg3,4
1Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
eNeuro
|August 29, 2023
概括
研究人员开发了一种负担得起的,可定制的16通道多电极阵列 (CMEA),用于在老鼠中同时记录局部场电位 (LFP). 这种轻量级,易于构建的阵列为大脑活动研究提供了具有成本效益的替代方案.
科学领域:
- 神经科学是一个神经科学.
- 生物工程是生物工程.
- 电力生理学 电力生理学
背景情况:
- 记录局部场势 (LFP) 对于理解大脑通信和节奏活动至关重要.
- 目前用于LFP数据收集的电极方法可能昂贵,复杂制造,并且缺乏适应多区域或同时记录的适应性.
- 需要可访问和多功能工具来研究研究环境中的神经活动.
研究的目的:
- 描述一个16通道可定制多电极阵列 (CMEA) 的构建过程.
- 提出一种具有成本效益和适应性的解决方案,用于同时从大鼠多个大脑区域记录LFP.
- 突出CMEA对初步神经活动研究的有用性.
主要方法:
- 16通道可定制多电极阵列 (CMEA) 的详细制造协议.
- 描述CMEA属性,包括重量 (<1g) 和构建时间 (<1h).
- 证明CMEA与有线和无线神经数据采集系统的兼容性,用于LFP,单单元和多单元活动记录.
主要成果:
- 开发的CMEA是轻量级的,快速构建的,并且价格极为实惠 (约合100美元). 15加拿大美元).
- 该CMEA使得自由行为大鼠从多个大脑区域同时记录LFP.
- 该阵列可以适应记录单单元和多单元活动,提供多功能性.
结论:
- 描述的CMEA提供了一个简单,低成本和高效的替代商业多电极阵列.
- 这种可定制的阵列促进了神经活动的初步研究,降低了研究人员的进入障碍.
- 在电生理学研究中,CMEA提高了多区域大脑活动记录的可访问性.
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