对于皮质神经发育的感觉运动关联轴的关键时期可塑性框架
Bart Larsen1, Valerie J Sydnor1, Arielle S Keller1
1Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn-CHOP Lifespan Brain Institute, Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Trends in neurosciences
|August 29, 2023
概括
人类大脑的发育遵循传感运动与关联 (S-A) 轴,可能是由成熟的临界期可塑性机制驱动的. 在体内神经成像技术的进步可能有助于测试这一假设.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 神经成像是一种神经成像.
背景情况:
- 人类大脑的发育涉及复杂的时空模式和潜在的神经生物学机制.
- 人类神经成像表明皮质发育的层次感官运动与关联 (S-A) 轴.
- 传统的神经成像努力阐明推动人类皮质发育的生物机制.
研究的目的:
- 假设人类S-A皮层发育轴是由级联的临界期可塑性机制驱动的.
- 探索体内神经成像如何将非侵入性信号与临界期机制联系起来.
- 促进对人类大脑发育的神经生物学基础的理解.
主要方法:
- 对现有的关于皮层发育的人类神经成像研究的审查.
- 对动物模型的检查,以确定可塑性的关键时期.
- 讨论最近在体内神经成像技术的进展.
主要成果:
- 动物模型揭示了保守的神经生物学机制,这些神经生物学机制控制了沿着皮层层次结构进步的可塑性的关键时期.
- 提出了一个假设,将人类SA发育轴与这些关键时期机制的成熟联系起来.
- 活体中神经影像提供了一种潜在的方法来研究人类的这种联系.
结论:
- 关键时期可塑性机制的成熟可能是人类感官运动与关联 (S-A) 皮质发育轴的关键驱动因素.
- 在体内神经成像为测试这个假设和理解人类神经发育提供了一个有前途的途径.
- 整合来自动物模型和人类神经成像的发现对于阐明发育机制至关重要.
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