人眼中的眼球类固醇组以及复杂的中央血清性胆色素变异症 (CSCR) 的眼睛
Marta Zola1,2,3, Elodie Bousquet1,2, Jean-Louis Bourges1,2
1Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France.
Scientific reports
|August 29, 2023
概括
这项研究揭示了慢性中央血清性胆色素病变 (CSCR) 的眼睛中类固醇激素水平的变化,显示活性较低的葡萄糖皮质体和活性较高的矿物质皮质体. 这一发现支持对抗性CSCR病例的新组合治疗方法.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 系统性和眼内源性皮质体 (类固醇体) 之间的关系尚未完全理解.
- 目前尚不清楚眼球类固醇组是否在中枢血清性胆色素病变 (CSCR) 的眼睛中发生变化.
研究的目的:
- 为了分析人体在水性幽默中的类固醇组,关于年龄,性别和一天的时间.
- 为了将全身和眼部的类固醇相对应.
- 分析慢性,不活跃的CSCR眼睛中的眼球类固醇组.
主要方法:
- 从未受影响的个人和CSCR患者中收集水性幽默 (AH),血清和玻璃体.
- 使用液体染色学-双重质谱法 (LC-MS/MS) 来量化13种内源性皮质体.
- 分析了与年龄,性别,昼夜节律和疾病状态有关的类固醇水平.
主要成果:
- 眼皮质醇水平明显低于血清水平,与全身皮质醇没有相关性.
- 血清和眼睛的皮质子水平显示出相关性,但只有不到5%的循环皮质子到达眼睛.
- 长期不活跃的CSCR眼睛表现出较低的活性葡萄糖皮质醇 (皮质醇) 和更高的活性矿物质皮质醇 (皮质/脱氧皮质比率).
结论:
- 眼球类固醇组受到高度调节,这表明局部眼球皮质体代谢.
- 慢性CSCR眼睛中葡萄糖皮质激素和矿物质皮质激素平衡的改变表明潜在的治疗点.
- 矿物质皮质素受体抗剂和葡萄糖皮质素滴剂的联合治疗在两个耐治疗的CSCR病例中显示出有利的结果.
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