老年人接种mRNA抗COVID-19疫苗四次的抗体反应
Alexander Rouvinski1, Ahuva Friedman2, Saveliy Kirillov2,3
1Department of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. alexander.rouvinski@mail.huji.ac.il.
Scientific reports
|August 29, 2023
概括
第四次mRNA疫苗剂量增加了抗体水平和老年人对COVID-19变种的中和能力. 持续的疫苗推广对这一群体来说是有价值的,即使是在Omicron突破感染后.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 老年学是一门学科.
背景情况:
- 在老年人中,对第四剂mRNACOVID-19疫苗的幽默免疫反应,特别是那些以前没有接触过SARS-CoV-2的人,需要进一步阐明.
- 了解疫苗在弱势群体中的有效性对于公共卫生战略至关重要.
研究的目的:
- 评估幽默免疫反应,包括血清抗RBDIgG水平和中和抗体能力,在mRNACOVID-19疫苗的第三和第四剂量后.
- 为了评估一个辅助生活设施的老年居民的反应,专注于没有以前的SARS-CoV-2感染的个人.
主要方法:
- 从46名老年居民 (平均年龄85岁) 的血清样本中,使用Abbott SARS-CoV-2 IgG II Quant测定分析了抗RBD IgG水平.
- 对武汉和Omicron BA.1 SARS-CoV-2变种的中和能力使用伪病毒测定进行了测量.
- 在第三次和第四次疫苗剂量之间比较了数据,并对已过去的时间进行了调整.
主要成果:
- 在接种第四剂疫苗后,针对RBD的平均血清IgG水平仍然与SARS-CoV-2-naïve参与者第三剂后76天的水平相当.
- 在第四剂量后,对武汉菌株和Omicron变种的中和抗体水平显著更高和更广泛.
- 患有Omicron突破性感染的个体表现出强有力的反应,表明疫苗预先适应而不是预防感染.
结论:
- 第四次mRNA疫苗剂量提高了老年人的幽默免疫力,包括对SARS-CoV-2变种的中和能力.
- 建议老年人继续接种疫苗以维持保护性免疫力.
- 这项研究强调了在老龄化人口中持续接种疫苗战略的重要性,这些人面临着不断演变的病毒变异.
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