产前暴露于常见的增塑剂:长度研究酸盐,大脑体积测量和青少年智商
Akhgar Ghassabian1,2, Michiel van den Dries3,4,5,6,7, Leonardo Trasande1,2,8,9
1Department of Pediatrics, New York University School of Medicine, New York, NY, USA.
Molecular psychiatry
|August 29, 2023
概括
产前接触酸盐,常见的塑化剂,与儿童灰质体积的减少有关. 这种大脑变化部分解释了与酸盐暴露相关的较低智商得分.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 儿科成像学 儿科成像学
背景情况:
- 酸盐是消费品中广泛使用的可塑剂和溶剂.
- 由于潜在的神经毒性,孕期甲酸盐暴露是一个越来越令人担忧的问题.
- 对产前甲酸盐暴露对大脑发育的影响的研究是有限的.
研究的目的:
- 调查产前甲酸盐暴露与儿童大脑体积测量之间的关联.
- 确定大脑结构变化是否调解了甲酸盐暴露和认知发育 (IQ) 之间的关系.
主要方法:
- 利用了775对母婴对在基于人口的R世代儿科神经成像研究中的数据.
- 在怀孕期间测量母亲尿液中甲酸代谢物度.
- 在10岁时使用T1加权MRI评估儿童大脑体积,在14岁时使用儿童智商.
主要成果:
- 较高的母体单乙烯甲酸盐 (mEP) 度与10岁后代的灰质总体体积较小有关.
- 总灰质体积部分介导了mEP暴露与儿童较低智商之间的联系.
- 单异丁甲酸盐 (mIBP) 暴露与女孩白质体积较小有关,调解了较低的智商.
结论:
- 产前甲酸盐暴露会影响到青春期的大脑体积测量.
- 观察到的大脑结构变化可能是与妊娠期甲酸盐暴露相关的认知缺陷的基础.
- 这些发现突出了怀孕期间暴露于甲酸盐的神经发育风险.
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