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肠道微生物组对乳腺癌预后的因果影响:孟德尔的随机化研究

Weimin Hong¹, Guoxin Huang², Danhong Wang³

¹General Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310000, China.

|August 29, 2023

概括

肠道微生物组与乳腺癌 (BC) 预后有因果关系,特定的细菌家族和属与不同的雌激素受体 (ER) 状态相关. 这项研究强调了肠道微生物群.

科学领域:

微生物组研究微生物组研究
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

新出现的证据表明,肠道微生物组组成与乳腺癌 (BC) 的发展和进展之间存在联系.
然而,肠道微生物组与BC预后之间的因果关系,特别是关于雌激素受体 (ER) 状态的因果关系,仍然在很大程度上未被探索.

研究的目的:

调查肠道微生物组与乳腺癌 (BC) 预后之间的因果关系.
探索不同雌激素受体 (ER) 状态之间的这些关联:ER-阳性 (ER+) 和ER-阴性 (ER-).

主要方法:

利用了来自乳腺癌协会联盟 (BCAC) 的全基因组关联研究 (GWAS) 数据集.
采用孟德尔随机化 (MR) 分析,主要使用逆方差加权 (IVW) 方法.
通过异质性测试,灵敏度分析和性质评估验证的结果.

主要成果:

确定了肠道微生物组与整体BC之间九种显著的因果关系.
发现了10个ER-负 (ER-) BC和9个ER-阳性 (ER+) BC的因果关系.
突出特定的细菌种群,包括Ruminococcaceae,Parabacteroides,Desulfovibrio,Sellimonas,Adlercreutzia和Rikenellaceae,与基于ER状态的BC预后相关.

结论:

证实了肠道微生物群在乳腺癌 (BC) 发展和预后中的因果作用.
提供了对不同雌激素受体 (ER) 状态的BC预后的特定细菌关联的见解.
已知的局限性包括潜在的弱仪器偏差和数据约束 (欧洲女性),强调需要进一步验证.

关键词:

乳腺癌乳腺癌是什么?我们的肠道微生物组.门德尔的随机化研究.雌激素受体的状态

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