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作为慢性偏头痛治疗响应的预测因素的皮肤全体:一个队列研究

Judith A Pijpers¹, Dennis A Kies^1,2, Erik W van Zwet³

¹Department of Neurology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.

The journal of headache and pain

|August 29, 2023

概括

缺少皮肤全发性肌痛预示着慢性偏头痛患者的成功治疗. 这一发现突出了所有作为偏头痛管理中中央敏感化和治疗反应的关键标志物.

科学领域:

神经学神经学
疼痛医学医学疼痛医学
临床试验临床试验

背景情况:

中心敏感化是偏头痛慢性化的一个关键机制.
皮肤全发性痛,是中央敏感化的症状,表现为头脑和脑外疼痛.
对于慢性偏头痛治疗响应的Allodynia亚型的预测价值仍然不清楚.

研究的目的:

为了调查皮肤全体的存在和空间分布是否能预测慢性偏头痛患者的治疗反应.
为了确定机械或热性全力学是否会影响治疗结果.

主要方法:

利用了CHARM研究的数据,这是一项随机,双盲,安慰剂控制的试验.
包括173名慢性偏头痛患者,过度使用药物.
使用Allodynia症状检查清单评估了基线皮肤整体肌痛;主要终点是回归到偶发性偏头痛.

主要成果:

74.6%的患者报告了皮肤全体性肌痛.
缺少全发性偏头痛预测回归到偶发性偏头痛 (OR:2.45,p=0.042).
预测值随着头部 (OR:4.16,p=0.024) 和头部外 (OR:7.32,p=0.003) 体缺失而增加. 机械体,而不是热,与结果有关.

结论:

皮肤全体是慢性偏头痛中中央敏感性的重要标志物.
缺少全发性偏头痛预测慢性偏头痛患者的治疗反应更好.
体的亚型,特别是它的空间分布,为治疗结果提供了进一步的预测价值.

关键词:

艾洛迪尼亚 (Allodynia) 是一种共享主义.生物标志物生物标志物中心敏感化中心慢性偏头痛是一种慢性偏头痛.过度使用药物过度使用药物.

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