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突触相关蛋白97对小脑功能连接性变化的遗传贡献在第一发精神分裂症中
Xusan Xu1,2, Shucun Luo3, Xiaoxia Wang1,4
1Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
突触相关蛋白97 (SAP97) rs3915512基因变异影响精神分裂症患者的大脑连接. 这种遗传因素影响小脑与其他大脑区域的沟通方式,影响临床症状.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症与皮质-下皮质-小脑电路的功能性失联有关.
- 突触相关蛋白97 (SAP97) 在小脑中大量存在,并与精神分裂症症状有关.
- 以前的研究表明,SAP97 rs3915512多态性与精神分裂症的临床结果之间存在联系.
研究的目的:
- 为了调查SAP97 rs3915512多态是否改变精神分裂症皮质-皮质下-小脑网络的静止状态功能连接 (RSFC).
- 探索第一个发作精神分裂症 (FES) 患者的改变连接性和临床表现之间的关联.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于104名汉族人 (52名FES患者,52名健康对照).
- 进行了兴趣区域 (ROI) 智能的功能连接性分析,以评估皮层/皮下区域和小脑之间的RSFC.
- 分析了SAP97 rs3915512多态的基因型数据,与RSFC和临床症状相关.
主要成果:
- 观察到精神分裂症和SAP97 rs3915512基因型对RSFC的交互作用在前额回环 (直肠) 和小脑之间.
- 在FES患有A等位基因的患者中,较高的小脑RSFC与敌意得分正相关.
- 在具有TT基因型的FES患者中没有发现这种相关性.
结论:
- SAP97 rs3915512多态可能通过调节小脑连接性来影响精神分裂症病理生理学.
- 由这种遗传变异影响的小脑连接性可能是一个中间的表型,将遗传风险与精神分裂症症状联系起来.
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