抗胆固醇药物与HIV感染者的跌倒和虚弱相关
Jessica Doctor1, Alan Winston2, Jaime H Vera3
1Guy's and St Thomas' NHS Foundation Trust, London, UK.
HIV medicine
|August 30, 2023
概括
抗胆固醇药物 (ACM) 与艾滋病毒感染的老年人中跌倒和虚弱的增加有关. 减少ACM的使用可能会改善这一群体的健康结果.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗胆固醇药物 (ACM) 与与年龄相关的不良结果有关,例如跌倒和虚弱.
- 艾滋病毒感染的老年人代表了这些与药物相关的风险的脆弱人群.
研究的目的:
- 调查抗胆固醇药物使用与艾滋病毒感染者50岁及以上老年人反复跌倒和虚弱之间的关联.
- 要量化与ACM使用相关的跌倒和虚弱风险在这个队列中.
主要方法:
- POPPY研究队列包括50岁以上的艾滋病毒感染者.
- 使用已建立的分数 (抗胆固醇负担,抗胆固醇风险,苏格兰大学间指南网络) 评估了抗胆固醇负担.
- 后勤回归模型被用来评估与反复跌倒和虚弱的关联,调整混因素.
主要成果:
- 28%的参与者使用了ACM,9%使用两个或两个以上.
- 与非使用者相比,ACM使用者的反复跌倒率 (17%vs. 6%) 和虚弱率 (32%vs. 17%) 显著更高.
- 使用两个或两个以上的ACM与跌倒 (OR 4.53) 和虚弱 (OR 2.26) 的几率增加有关.
结论:
- 抗胆固醇药物经常被处方给艾滋病毒感染者.
- 在这种人群中,ACM使用与反复跌倒和虚弱的风险增加之间存在显著的关联.
- 临床医生应仔细审查并尽量减少艾滋病毒感染的老年人ACM暴露,以减轻这些风险.
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