狗颜色病毒斑块的临床,组织病理和分子特征
Margherita Orlandi1, Maurizio Mazzei2, Francesco Albanese1
1Private Veterinary Laboratory "MyLav," Passirana di Rho, Italy.
Veterinary pathology
|August 30, 2023
概括
狗颜色病毒斑 (PVPs) 是由狗乳头瘤病毒 (CPVs) 引起的良性皮肤生长. 这项研究详细介绍了它们的流行病学,临床症状,并确定CPV-9为最常见的类型,手术切除对单个病变有效.
科学领域:
- 兽医皮肤病学 兽医皮肤病学
- 狗类病理学 狗类病理学
- 病毒瘤学 病毒瘤学
背景情况:
- 狗颜色病毒斑块 (PVPs) 是由狗乳头瘤病毒 (CPVs) 引起的表皮增殖.
- 关于PVP的现有文献有限,重点是基因组测序,而不是全面的临床数据.
- 虽然PVP的新塑性转化很少见,但已被记录下来,这凸显了进一步调查的必要性.
研究的目的:
- 调查犬类PVP的流行病学,临床病理学特征和基因定型.
- 分析患有PVP的狗的治疗结果和预后.
- 为了确定与意大利PVP相关的特定犬类乳头瘤病毒.
主要方法:
- 55只狗PVP的回顾性分析,包括组织学评估和后续数据.
- 记录了临床表现,品种偏好,病变分布和治疗反应.
- 狗乳头瘤病毒 (CPV) 的基因定型使用测序进行,用于病毒检测的L1免疫标记.
主要成果:
- 马是受影响最多的品种 (25%),平均年龄为6.5岁.
- 多重病变很常见 (75%),经常发生在腹部和部.
- 狗乳头瘤病毒9型 (CPV-9) 在71%的基因型病例中被确定. 手术切除对于单个病变是有效的,而对多个病变的医疗治疗显示出有限的成功. 在9%的病例中,观察到与PVP相邻的新生病,其中包括一种侵入性状细胞癌.
结论:
- 这项研究提供了关于犬类PVP的广泛数据,包括流行病学,临床表现和治疗结果.
- 狗乳头瘤病毒9型是研究的意大利队列中与PVP相关的主要病毒类型.
- 狗PVP的有效管理策略需要进一步的研究,特别是在多重或普遍的病变.
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