杜皮卢马布诱导的眼睛表面疾病:一个潜在的病例系列
Sayali Prakash Pradhan1, Salman Naveed Sadiq1, Cristian Cartes1,2
1Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
European journal of ophthalmology
|August 30, 2023
概括
杜皮卢马布诱导的眼表面疾病 (DIOSD) 影响了近30%的亚托皮炎患者. 及时的局部治疗可以改善结果和患者满意度,而无需停止使用Dupilumab.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 亚托皮炎 (AD) 是一种慢性炎症性皮肤疾病.
- 杜皮卢马布是一种针对IL-4和IL-13通路的生物疗法,有效治疗AD.
- 眼睛表面疾病可能是阿尔茨海默病及其治疗的并发症.
研究的目的:
- 为了确定在阿托皮性皮肤炎患者中杜皮卢马布诱导的眼表面疾病 (DIOSD) 的发生率,危险因素,人口统计和临床特征.
- 为DIOSD提出一个标准化治疗方案 (STP).
- 为了评估DIOSD患者的治疗反应.
主要方法:
- 用dupilumab治疗的阿托皮性皮炎患者的未来病例系列.
- 监测了眼部症状和眼部表面疾病指数 (OSDI).
- 标准局部治疗被处方,并评估反应.
主要成果:
- 28.31%的患者患上了DIOSD,在开始使用dupilumab后的中位数发病时间为9.2周.
- 结膜炎和白炎是常见的表现.
- 局部治疗导致症状和OSDI得分显著改善,没有停止使用dupilumab.
结论:
- DIOSD是dupilumab在阿托皮性皮肤炎患者中常见的一种不良反应.
- 及时转诊和适当的局部治疗对于有效管理DIOSD至关重要.
- 有效的管理允许在不停止治疗的情况下继续治疗dupilumab.
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