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在输血的无塑性贫血和骨髓纤维化患者中,红细胞与免疫率的增加

G Sotolongo¹, J L Poisson¹

¹Department of Pathology, Duke University Hospital, Durham, North Carolina, USA.

|August 30, 2023

概括

红细胞 (RBC) 配免疫 (AI) 在依赖输血的患有无塑性贫血 (AA) 和骨髓纤维化 (MF) 的患者中更为常见. 这些患者经历了较高的红细胞AI率,这表明需要抗原匹配协议来减少并发症.

科学领域:

血液学血液学血液学
免疫学免疫学免疫学
输血医学输血医学

背景情况:

红细胞 (RBC) 配免疫 (AI) 是红细胞输血的一个已知的并发症,导致配抗体的形成和输血风险.
需要输血的患者,包括患有无形性贫血 (AA) 和骨髓纤维化 (MF) 的患者,面临更高的红细胞AI风险.
有限的研究存在于RBCAI在特定的输血依赖人群,如AA和MF.

研究的目的:

在AA和MF患者中调查红细胞AI的流行率和alloantibody发病率.
为了将AA和MF患者的红细胞AI率与一般住院人口进行比较.
为了确定这些患者群体中开发的常见的alloantibodies.

主要方法:

在一家医院系统内进行了5年的回顾性审查.
收集的数据包括红细胞AI流行率,抗体发生率以及AA和MF患者的红细胞输血数量.
患者队列包括64名AA和93名MF患者.

主要成果:

与普通人群相比,AA和MF患者的RBCAI发病率显著增加 (分别为14.1%和12.9%),比一般人群 (1%-2%).
原发性髓纤维化患者的显着孤立RBCAI发病率为13.3%.
最常被发现的alloantibodies是抗E和抗K.

结论:

患有AA和MF的患者表现出高于一般住院人口的红细胞AI发病率.
实施抗原匹配输血协议可能对AA和MF患者有益,以减轻AI相关的并发症.

关键词:

红细胞输血红细胞输血免疫血液学 (红细胞血清学,血型)输血并发症 - 非传染性

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