在接受阿片类药物使用障碍阿片类药物agonist治疗的人群中,delta-9-tetrahydrocannabinol调节疼痛敏感性:一个在人体内,随机,安慰剂控制的实验室研究
Joao P De Aquino1,2,3, Julia Meyerovich1,2, Catherine Z Xie4
1Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Addiction biology
|August 30, 2023
概括
这项研究发现,10mg的delta-9-tetrahydrocannabinol (THC) 在接受美沙治疗的阿片类药物使用障碍 (OUD) 患者中,比20mg更能提供自我报告的疼痛缓解. 没有观察到任何显著的相互作用或滥用潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 成 药物 药物 药物 药物
背景情况:
- 阿片类药物和大麻素系统相互连接,临床前数据表明协同缓解疼痛.
- 有限的人类数据存在于接受阿片类药物使用障碍 (OUD) 的阿片类药物主体疗法的人群中的大麻素效应.
研究的目的:
- 研究delta-9-tetrahydrocannabinol (THC) 对患者疼痛敏感性,滥用潜力,认知和生理学的急性影响.
主要方法:
- 一项人体内,交叉,人体实验室研究,涉及25名参与者接受OUD的甲治疗.
- 参与者在随机交叉设计中接受单次口服THC剂量 (10mg或20mg作为dronabinol) 或安慰剂.
- 评估疼痛敏感性 (实验和自我报告),滥用潜力,认知功能和生理反应.
主要成果:
- 10毫克THC与20毫克THC相比,提供了更大的自我报告的疼痛缓解;实验疼痛敏感度没有显著差异.
- 观察到不一致的,剂量依赖的认知不良影响.
- 没有发现滥用潜力或THC和甲剂量之间的显著相互作用的实质证据.
结论:
- 大麻素,特别是THC,可以为在甲治疗中的OUD患者提供疼痛缓解,潜在的最佳剂量为10mg.
- 需要进一步的研究来充分评估大麻素在这个人群中的风险益处概况,特别是考虑到正在进行的阿片类药物危机.
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