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与纵向[18F]AZD4694 PET一起积聚的粉样β斑块

Joseph Therriault^1,2, Firoza Z Lussier^1,2,3, Cécile Tissot^1,2

¹Translational Neuroimaging Laboratory Douglas Mental Health Institute McGill University Research Centre for Studies in Aging Montreal Quebec Canada.

Alzheimer's & dementia (Amsterdam, Netherlands)

|August 30, 2023

概括

这项研究表明,通过[18F]AZD4694测量的粉样β (Aβ) 积累随着时间的推移而增加,特别是在现有Aβ病理的个体中. 这种PET追踪器可以在临床试验和环境中监测Aβ水平.

科学领域:

神经成像是一种神经成像.
阿尔茨海默氏症疾病研究研究
生物标志物开发生物标志物开发

背景情况:

[18F]AZD4694是一种成熟的粉样β (Aβ) 成像剂.
使用[18F]AZD4694的纵向Aβ积累数据一直缺乏.
了解Aβ动态对于阿尔茨海默病研究至关重要.

研究的目的:

使用[18F]AZD4694.4 评估纵向的Aβ积累.
量化Aβ沉积量的年度变化率.
评估[18F]AZD4694在追踪疾病进展中的实用性.

主要方法:

146名患者在基线和2年随访期间接受了[18F]AZD4694的PET成像.
计算了[18F]AZD4694标准化吸收值比率 (SUVR) 变化的年率.
参与者被分为临床定义和生物标志物定义的群体.

主要成果:

认知不受损的老年人显示微妙的[18F]AZD4694 SUVR增加.
具有Aβ阳性的认知不受损的个体表现出更高的年度[18F]AZD4694 SUVR增加.
有Aβ阳性的轻度认知障碍和痴呆症显示了适度的新皮层[18F]AZD4694 SUVR积累.

结论:

[18F]AZD4694 PET可以追踪纵向的Aβ积累.
较高的基线Aβ负担与更大的[18F]AZD4694 SUVR增加有关.
[18F]AZD4694对于在临床试验和环境中监测Aβ非常有价值,特别是在抗粉样蛋白疗法之前.

关键词:

阿尔茨海默氏症的疾病是阿尔茨海默氏症.氨基βββββββββββββββββββββββββ 定子发射断层扫描 (PET).

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