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在治疗双相情感障碍患者的强迫症治疗中,阿里皮普拉和瑞斯比龙的有效性比较:双盲随机临床试验
Faezeh Khorshidian1, Angela Hamidia1, Farzan Kheirkhah1
1Department of Psychiatry, School of Medicine, Health Research Institute Babol University of Medical Sciences Babol Iran.
Health science reports
|August 30, 2023
概括
当与酸相结合时,阿里皮普拉和Risperidone有效地治疗具有双相情感障碍的强迫症 (OCD). 与Risperidone相比,阿里皮普拉在减少强迫症症状方面表现出更高的有效性.
科学领域:
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
- 神经科学是一个神经科学.
背景情况:
- 强迫症 (OCD) 呈现出慢性,波动的症状,使治疗复杂化,特别是在并发性双相情感障碍 (BD) 患者中.
- 由于症状重叠和治疗复杂性,在BD患者中治疗强迫症是一个重大的临床挑战.
研究的目的:
- 为了比较Aripiprazole与Risperidone的疗效和安全性,作为对甲的辅助治疗.
- 评估这些辅助疗法的对伴随性强迫症-BD患者的躁狂,抑郁和强迫症症状的影响.
主要方法:
- 一个三阶段,双盲,随机的临床试验,涉及64名根据DSM-5标准被诊断患有强迫症和BD的患者.
- 患者接受了酸,其中一组额外接受了阿里皮普拉治疗,另一组接受了Risperidone治疗.
- 症状严重程度使用耶鲁-布朗强迫症-强迫症量表 (Y-BOCS),年轻躁狂评分量表 (YMRS) 和汉密尔顿抑郁症评分量表 (HAM-D) 进行评估.
主要成果:
- 无论是阿里皮普拉还是瑞斯比,都显著降低了躁狂,抑郁和强迫症症状得分.
- 与瑞士相比,阿里皮普拉在强迫症的Y-BOCS得分中显示出明显更大的降低 (p < 0.001).
- 里斯佩里与显著的体重增加有关,而阿里皮普拉导致显著的睡眠障碍.
结论:
- 阿里皮普拉和利斯佩里是有效和安全的辅助疗法与酸在BD患者的强迫症治疗.
- 与Risperidone相比,阿里皮普拉在这种患者群体中治疗强迫症症状方面表现出更高的疗效.
- 这两种药物都可以在没有严重副作用的情况下使用,提供了可行的治疗选择.
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