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单细胞蛋白质基因组数据的建模和解释.

Andrew Leduc1, Hannah Harens1, Nikolai Slavov1,2

  • 1Departments of Bioengineering, Biology, Chemistry and Chemical Biology, Single Cell Proteomics Center, and Barnett Institute, Northeastern University, Boston, MA 02115, USA.

ArXiv
|August 30, 2023
PubMed
概括

新的质谱法允许高通量单细胞蛋白质组学,补充基因组学. 这允许以单细胞分辨率对协调蛋白质和核酸的分子机制进行数据驱动的建模,以获得生物学见解.

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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