在COVID-19感染后,新诊断的原性脱线性损伤和多发性硬化症
Tuğba Erdoğan1, Belgin Koçer1, Sedat Şen2
1Gazi University School of Medicine, Department of Neurology, Ankara, Turkey.
Noro psikiyatri arsivi
|August 30, 2023
概括
COVID-19 感染可能引发或恶化中枢神经系统 (CNS) 脱髓化疾病,包括多发性硬化症 (MS) 和瘤性脱髓化病变 (TDL). 这表明SARS-CoV-2可以在MS和相关疾病的临床发病中发挥作用.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- COVID-19已与各种神经系统并发症有关.
- 对脱髓化疾病的副传染性或后传染性影响需要进一步研究.
研究的目的:
- 描述COVID-19对多发性硬化症 (MS) 的初始表现和长度扩展性横侧髓炎 (LETM) 的瘤性脱髓化病变 (TDLs) 的影响.
主要方法:
- 一系列6名患者的病例,在COVID-19感染后出现新发作或加重的中枢神经系统脱髓化.
- 分析临床症状,神经症状以及放射和脑脊液 (CSF) 发现.
- 在鼻和脑液上的SARS-CoV-2 PCR测试.
主要成果:
- 五名患者通过鼻抽样PCR检测出SARS-CoV-2阳性,一名通过脊髓PCR检测出阳性.
- 四名患者被诊断出他们的第一个MS表现,一个患有临床隔离综合征.
- 病例显示显著的大脑和/或脊髓MRI病变,包括TDLs和LETM,表明COVID-19后中枢神经系统脱髓化疾病活动中度.
结论:
- COVID-19 感染可能引发或加剧中枢神经系统脱髓化疾病,如多发性硬化症.
- 在MS的临床发病过程中,SARS-CoV-2似乎起到了作用.
- 主动脱髓化发生在三个月内,可能是由于COVID引发的神经免疫反应.
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