一项针对宫癌风险分层查的试点研究
Jiangrong Wang1, K Miriam Elfström2,3, Christer Borgfeldt4
1Department of Laboratory Medicine, Karolinska Institute, SE-141 52 Stockholm, Sweden.
Open research Europe
|August 30, 2023
概括
使用人类乳头瘤病毒 (HPV) 自取样本测试进行风险分层子宫癌查是可行的. 短信服务 (SMS) 对高风险女性的邀请增加了对HPV检测的试剂盒要求和样本提交.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 妇科 妇科 妇科 妇科
背景情况:
- 根据查史和人类乳头瘤病毒 (HPV) 类型,子宫癌的风险有很大差异.
- HPV 疫苗接种正在减少致癌类型的感染,需要量身定制的查方法.
- 风险分层查旨在通过个性化查强度来提高敏感性和特异性.
研究的目的:
- 评估风险分层的宫癌查的可行性和可接受性.
- 评估高风险女性吸收阴道HPV自取样套件的情况.
- 确定短信和实物信件的有效性,以邀请女性参与.
主要方法:
- 根据非典型的腺细胞或不正常的发现,没有足够的随访,确定了高风险女性.
- 通过短信或实物信件邀请女性在线订购HPV自取样套件.
- 测试返回了高风险HPV (hrHPV) 的自收集样本,并为阳性病例提供了临床随访.
主要成果:
- 在920名目标女性中,有191名 (21%) 订购了套装,163名 (18%) 返回了样品.
- 19个样本 (12%) 呈 hrHPV 阳性检测结果.
- 在19名 hrHPV 阳性女性中,有18名女性参加了临床随访.
结论:
- 通过实物信件补充的短信邀请是吸引高风险女性参加宫癌查的可行方法.
- 试点研究表明,对HPV自取样本的实质性兴趣和参与.
- 未来的努力将集中在优化流程和提高整体出席率上.
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